Since the COVID-19 pandemic, RNA-based therapies have experienced an unprecedented surge, showcasing their potential to revolutionize medicine. While mRNA vaccines dominated headlines, the real promise of RNA lies in its ability to treat a wide range of diseases, from cancer to rare genetic disorders. In Québec, a region known for its strength in life sciences, the newly launched AReNA (ARN Québec) initiative is paving the way to make RNA therapeutics a cornerstone of the province’s biotech future.